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Health
supplements - Contraindications, and drug interactions with
some medicines
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Vitamin/
Mineral
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Common Uses
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Usual Dose
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Contraindications
and Precautions
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Drug Interactions
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Vitamin A
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Essential in maintaining normal
growth of epithelial cells
Helps in night vision
Maintains healthy nervous system
Vitamin A deficiency may increase
your susceptibility to infections
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Adult RDA: 5000iu / day
Zinc helps in absorption of Vit
A
Found in cod liver oil capsules
and emulsions
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Avoid excessive doses during pregnancy.
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None known
When taken in large amounts, vit
A will enhance action of warfarin.
Mineral oil, Orlistat, Cholestyramine
may reduce vit A absorption.
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Vitamin C
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Helps body resist infections
Helps in wound healing
Helps in absorption of iron and
calcium
Maintains healthy skin, tissues
and blood vessels
Protects against cataract
The need for vit C increases when
the body is subjected to trauma, infections, strenuous
exercise or if the person is a smoker.
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RDA: 60mg /day
Studies show up to 3000mg may be
beneficial; excess amount passes into urine, does not
store in the body
Available in chewable tablets, effervescent
tablets, sustained release formulations, Ester C, and
acid free formulations ( for those with gastric problems)
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Mega doses should be avoided in
those with history of renal stones
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Antacids, alcohol, cholestyramine,
antidepressants, birth control pills may deplete vit
C.
Reduce effect of cholestyramine
and warfarin.
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Vitamin E
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Antioxidant
Maintains healthy skin and hair
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200 - 400iu / day
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None known
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None known
When taken in large amounts, vit
E mayl enhance action of warfarin.
Will impair iron absorption (best
not be taken at the same time) .
Mineral oil, Orlistat, Cholestyramine
should not be taken with vitamin E as they reduce vitamin
E absorption.
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Zinc
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Boosts immunity
Required for cell division and cell
growth
Aids wound healing
Maintains normal sense of taste
and smell
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15-30mg / day
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toxic in high dose (induce copper
deficiency)
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Soya, milk, iron supplements, whole
wheat bread and bran can interfere with zinc absorption
Avoid taking with calcium ( reduces
zinc absorption by 50%)
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Selenium
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Antioxidant
Males appear to have a greater need
for selenium. Almost half their body's supply concentrate
in the testicles and is lost in semen.
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50- 200mcg / day
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None known
Multiple side effect in large dose.
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None known
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Folic Acid
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Helps to strengthen immune system
Prevent neural tube defect
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RDA : 400mcg / day
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Can mask vit B12 deficiency
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Folic acid slightly reduces the
body's ability to absorb and retain zinc
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Herb
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Common Uses
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Usual Dose
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Interactions/
contraindications
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Drug Interactions
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Colostrum
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Supplementation of immune factors,
antibodies, and other proteins.
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10g/day.
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Avoid in pregnancy and breastfeeding.
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None reported.
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Echinacea
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Prevention and treatment of the
common cold.
Prevention and treatment of damage
by UV/UVB radiation.
Wound healing.
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6-9ml/day of the root or
900mg/day of the leaf.
NB: Course of 7-14 days. Do not
take for > 8 consecutive weeks
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Allergy to Echinacea or alcohol
(as tinctures may contain alcohol).
Avoid in pregnancy and breastfeeding.
Patients with severe illnesses.
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None reported.
Not to be taken with steroid, methotrexate,
amidarone, ketoconazole as may induce liver toxicity.
Antagonise effect of immuno-suppresants.
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Garlic
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Antimicrobial.
Thins blood.
Prevention and treatment of high
cholesterol.
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4g/day of freshly minced garlic
bulb, or
600-900mg/day of dried garlic powder.
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Allergy to garlic.
Avoid in pregnancy.
May worsen stomach ulcers or acid
reflux problems.
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May increase risk of bleeding if
used with drugs that thin the blood e.g. warfarin, aspirin.
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Ginseng
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Enhances immune function.
Anti-fatigue.
Anti-stress.
Antioxidant.
Prevention of high cholesterol.
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100-300mg/day.
Depends on where the plant grew
and extraction techniques.
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Allergy to ginseng.
May decrease blood glucose in diabetics.
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May decrease warfarin activity.
May interfere with digoxin activity.
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Green Tea
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Antimicrobial.
Anti-mutagenic.
Antioxidant.
Prevention of high cholesterol.
Cancer, dental caries.
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3 to 6 cups daily.
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Allergy to green tea.
Green tea contains caffeine. Avoid
in pregnant women.
May cause asthma attacks in some
susceptible asthmatics.
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Increase effect anticancer drug,
Doxorubicin.
Milk may inhibit antioxidant effect
of green tea.
May increase effect of warfarin.
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RDA = recommended daily allowance
The information provided is not meant
to advocate the use of any health supplement. You should always
consult your pharmacist for advice before consuming any supplements.
References:
1. Earl
Mindell's Vitamin Bible.
2. "Which Vitamins
Do you Need" John Capri.
3. Fetrow CW and Avila
JR. Professionals’ Handbook of Complementary & Alternative
Medicines 2nd ed. Springhouse Corporation 2001.
4. The Review of Natural
Products. DerMarderosian and Beutler (eds). Facts and Comparisons
2003.
5. Herbal Medicine : Expanded
Commission E Monographs. Blumenthal, Goldberg and Vbrinckmann
(eds) Amercian Botanical Council 2000.
6. Heck A, Dewitt B, Lukes
A. Potential interactions between alternative therapies and
warfarin. AmJ Health-Syst Pharm. 2000;57:1221-1230.
7. Pharmacy Today. Published
by American Pharmaceutical Society. 1999.
8. Non prescription handbook.
9. Drug Information handbook.
10. Incorporating Herbal medicine into clinical
practice.
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