Commentary: Can chloroquine really treat COVID-19?
A medicinal chemist addresses questions about chloroquine and hydroxychloroquine: What it is, whether it is effective against COVID-19 and whether it can treat or prevent this disease.
BALTIMORE, Maryland: An Arizona man died, and his wife was hospitalised, after taking a form of chloroquine, which US President Donald Trump has touted as an effective treatment for COVID-19.
The couple decided to self-medicate with chloroquine phosphate, which they had on hand to kill parasites in their fish, after hearing the president describe the drug as a “game changer”.
Dr Anthony Fauci, head of NIH’s National Institute for Allergies and Infectious Diseases, quickly corrected the statement, explaining that Trump’s comments were based on anecdotes and not a controlled clinical trial.
As a medicinal chemist who specialises in the development of antiviral drugs and work on the coronaviruses for seven years, I am concerned about the sweeping statements the president has been making regarding the use of chloroquine or the closely related hydroxychloroquine, both antimalarial drugs, as cures for COVID-19.
CAN CHLOROQUINE OR HYDROXYCHLOROQUINE WORK ON COVID-19?
Chloroquine and hydroxychloroquine are both US Food and Drugs Administration-approved antimalarial drugs that have been in use for many years.
Chloroquine was originally developed in 1934 at the pharmaceutical company Bayer and used in World War II to prevent malaria.
Although the FDA has not approved its use for these conditions, both chloroquine and hydroxychloroquine are also used to treat rheumatoid arthritis and lupus.
After the initial outbreak of MERS in 2012, scientists conducted random screens of thousands of approved drugs to identify one that might block MERS infection.
Several drugs, including chloroquine, showed the ability to block coronaviruses from infecting cells in vitro. But these drugs were not extensively pursued because ultimately they did not show enough activity to be considered further.
When the new coronavirus appeared, many drugs that had shown some initial promise against the related coronaviruses MERS and SARS were at the top of the list as worthy of further evaluation as possible treatments.
So the science is real, and a number of labs around the world are now investigating these drugs and testing them in clinical trials in the US, France and China.
But so far, there is no consensus about whether the drugs are safe and effective for treating COVID-19, as it is still very early in the testing process.
WHY WOULD ANTI-MALARIAL DRUGS WORK ON A VIRUS?
It is still unclear how the chloroquines (or any antimalarial drug) would work against COVID-19, which is a virus. Malaria is caused by plasmodium parasites that are spread by mosquitoes, whereas COVID-19 is caused by the SARS-CoV-2 virus.
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Viral infections and parasitic infections are very different, and so scientists wouldn’t expect what works for one to work for the other. It has been suggested that the chloroquines can change the acidity at the surface of the cell, thereby preventing the virus from infecting it.
It’s also possible chloroquines help activate the immune response. One study that was just published tested hydroxychloroquine in combination with an antibacterial drug (azithromycin), which worked better to stop the spread of the infection than hydroxychloroquine alone. However it’s only one preliminary study that was done on a limited test group.
ARE OTHER DRUGS PROMISING?
To my knowledge, no other antimalarial drugs have shown any meaningful activity against treating coronaviruses. However, another potential drug has risen to the forefront.
Remdesivir, developed by Gilead Pharmaceuticals, seems to be highly effective at preventing viruses – including coronaviruses such as SARS and MERS, and filoviruses such as Ebola – from replicating.
In late February the National Institute for Allergy and Infectious Diseases launched a clinical trial for Remdesivir. And this month Gilead launched two phase III trials of the drug in medical centres in Asia.
SHOULD I TAKE THEM TO WARD OFF THE CORONAVIRUS?
But you absolutely should not take any of these drugs to ward off the coronavirus. Chloroquine and hydroxychloroquine have not been appropriately evaluated in controlled studies, not to mention that they have numerous and, in some cases, very deadly side effects.
No one should take a drug that has not been proven to be safe and effective for a disease or condition for which it is not approved.
There are just so many issues that can arise, from side effects to serious toxicity and death due to possible interactions with other medications and other underlying health conditions.
So until these or any drugs have been shown to be effective against SARS-CoV-2 in clinical trials and have been approved by authorities, no one should be self-medicating.
Katherine Seley-Radtke is Professor of Chemistry and Biochemistry and President-Elect of the International Society for Antiviral Research, University of Maryland, Baltimore County. This commentary first appeared on The Conversation.