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Commentary: Should COVID-19 doses be split to cover more people?

Veering off-script in the COVID-19 vaccine rollout may just be in the public interest, says Anjana Ahuja.

Commentary: Should COVID-19 doses be split to cover more people?

A droplet falls from a syringe after a health care worker was injected with the Pfizer-BioNTech COVID-19 vaccine at Women & Infants Hospital in Providence, on Dec 15, 2020. (Photo: AP/David Goldman)

LONDON: In 2016, as a yellow fever outbreak crept closer to major cities in Angola and the Democratic Republic of Congo, the World Health Organization took a calculated gamble.

Faced with vaccine shortages, it recommended the splitting of doses. More than 7 million children and adults in Kinshasa, among others, received only a fifth of the usual dose.

That fractional amount, researchers later found, induced good levels of protective antibodies that were still detectable a year later. A year of protection is better than none in a raging epidemic.

Could veering off-script in the rollout of COVID-19 vaccines also be in the public interest?

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The Pfizer/BioNTech vaccine, the first to be deployed in the US and UK, officially requires two doses given 21 days apart.

But, instead of issuing first doses and reserving supplies to give boosters later, some people advocate dispensing all doses now and giving boosters when further supplies allow.

In the US, this option means 40 million would get a first dose of the Pfizer/BioNTech vaccine, instead of 20 million receiving two doses.

The UK is currently rolling out 800,000 doses, with another 4 million due by the end of December.

IMMEDIATE DEPLOYMENT COULD MAXIMISE UTILITY OF VACCINE

The idea was floated recently by Scott Gottlieb, the former head of the US Food and Drug Administration who now sits on the board of Pfizer.

People wait in line at the St Clements Food Pantry for food in the Manhattan borough of New York City on Dec 11, 2020. (Photo: Reuters/Carlo Allegri) People wait in line at the St. Clements Food Pantry for food during the coronavirus disease (COVID-19) pandemic in the Manhattan borough of New York City, New York, U.S., December 11, 2020. REUTERS/Carlo Allegri

“I feel very strongly that we should get as many shots in arms as possible, right away,” Mr Gottlieb told USA Today last week.

“The reality is that one dose is partially protective. I just fundamentally disagree with [saving half the supply for January].”

The vaccine is 52 per cent effective after the first dose, rising to 95 per cent after the booster.

READ: Commentary: Let’s switch from wanting to be COVID-free to becoming COVID-vigilant

His view is that immediate deployment maximises the health benefits of a life-saving intervention. It is not a risk-free strategy: Unforeseen delays to supplies next year could hamper the rollout of boosters.

Still, leaving vulnerable people unvaccinated while second doses languish for weeks in fridges, is also a risk.

READ: Commentary: Phase 3 will bring us much-needed closure to a difficult year

NO EVIDENCE THAT BOOSTERS MUST BE TIMED PRECISELY

There is another point in Mr Gottlieb’s favour: There is no firm evidence that boosters must be timed precisely to be efficacious. While second doses dramatically enhance protection, dosing intervals are not set by any immutable commandments of vaccinology.

The WHO vaccine tracker, for example, shows a variety of dosing schedules, mostly modelled on past convention.

“It’s like a random number generator,” says Danny Altmann, professor of immunology at Imperial College London.

The first vials of Pfizer-BioNTech COVID-19 vaccine sit in a refrigerator at Ochsner Hospital on O'Neal Lane, Dec 15, 2020, in Baton Rouge, La. (Photo: AP/The Advocate/Bill Feig)

“Some doses are 28 days apart, while others are 21 or 14. That doesn’t reflect the fundamentals of the immune system but a tweaking of the trials that gave slightly better data.

“You could probably merge them all and come out with one common protocol that would work pretty well for all of them.”

A handful of trials have offered a second or third dose on day 56. 

Intriguingly, in the Oxford/AstraZeneca vaccine trial, some volunteers in the under-55 subgroup showing the highest efficacy had their second jabs as long as eight weeks after the first.

Routine boosters for other diseases are also put off for multiple reasons – holidays, clinic closures, delayed deliveries, forgetfulness – without efficacy being a worry.

READ: Commentary: This university is rolling out the COVID-19 vaccine for staff and students. It's a lot of work

As Professor Altmann concludes: “If I were an NHS adviser or a vaccine producer running a huge logistical operation, I’d probably want to stick to protocol.

“But if you ask me: Does the timing of the booster really, really matter all that much? Probably not."

“In vaccinology, when push comes to shove, if we’re trying to save lives we sometimes break protocol, as happened with yellow fever.”

READ: Commentary: Concerns over severe allergic reactions to COVID-19 vaccines don't outweigh benefits of vaccination

UNEXPECTED BENEFITS OF BREAKING CONVENTION

The coronavirus pandemic also shows that, in extremis, vaccinology conventions can be challenged.

Oxford University and AstraZeneca have developed one of the promising Covid-19 vaccines AFP/JOEL SAGET

The dosing error that dogged the Oxford/AstraZeneca trial was unexpectedly associated with better results.

Scientists have not ruled out mixing and matching first and second doses from different vaccines, depending on availability.

Volunteers who drop out of clinical trials after a first dose of one COVID-19 vaccine in order to receive a different, approved jab, will be a fascinating cohort to watch.

READ: Commentary: So the vaccines are here, but how will they get to billions across the globe?

There might be just enough scientific leeway, and encroaching danger, to reasonably discuss bending the rules to deploy all COVID-19 vaccine doses now.

Christmas approaches. Infection rates are rising. Hospitals are filling up. More vaccines are coming next year.

Mr Gottlieb’s approach of emptying the armoury now is a gamble – but so is holding back half of the ammunition when other cavalries are on their way.

Listen to infectious disease experts discuss what a COVID-19 vaccine rollout would look like:


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Source: Financial Times/el

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