Commentary: Majority who have COVID-19 may not show symptoms but more research needed

Commentary: Majority who have COVID-19 may not show symptoms but more research needed

COVID-19 is different to previous epidemics such as SARS, where most of the infections were symptomatic and could be traced, says an observer.

Passengers wearing protective face masks, following an outbreak of the coronavirus disease, walk to
Passengers wearing protective face masks are seen at a station in Tokyo, Japan, Apr 7, 2020. (Photo: Reuters/Issei Kato)

LONDON: The COVID-19 pandemic continues to spread, with 1.4 million cases and almost 75,000 deaths reported worldwide as of Apr 7.

To slow down the spread and reduce mortality, governments across the world have put in place social distancing measures. When such measures are lifted, the “flattened epidemic curve” is expected to start rising again in the absence of a vaccine.

As most testing takes place inside hospitals in the UK and many other countries, the confirmed cases so far largely capture people who show symptoms.

But to accurately predict the consequences of lifting the restrictions, we need to understand how many people with COVID-19 don’t show symptoms and to what extent they are contagious.

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ASYMPTOMATIC CASES

A recent study, published in the British Medical Journal (BMJ), suggested that 78 per cent of people with COVID-19 have no symptoms.

The findings are in line with research from an Italian village at the epicentre of the outbreak showing that 50 per cent to 75 per cent were asymptomatic, but represented “a formidable source” of contagion.

A recent Icelandic study also showed that around 50 per cent of those who tested positive to COVID-19 in a large-scale testing exercise were asymptomatic.

FILE PHOTO: A logo is pictured on the World Health Organization headquarters in Geneva
FILE PHOTO: A logo is pictured on the World Health Organization (WHO) headquarters in Geneva, Switzerland, November 22, 2017. REUTERS/Denis Balibouse/File Photo

Meanwhile, a WHO report found that “80 per cent of infections are mild or asymptomatic, 15 per cent are severe infections and 5 per cent are critical infections”.

Though we don’t know what proportion of that 80 per cent were purely asymptomatic, or exactly how the cases were counted, it again points to a large majority of cases who are not going into hospital and being tested.

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NEW DATA

The new BMJ study is seemingly different to the findings of studies from earlier in the pandemic, which suggested that the completely asymptomatic proportion of COVID-19 is small: 17.9 per cent on the Diamond Princess Cruise Ship and 33.3 per cent in Japanese people who were evacuated from Wuhan.

The new paper is based on collated data that Chinese authorities began publishing daily from Apr 1 on the number of new coronavirus cases in the country that are asymptomatic.

It reports that “a total of 130 of 166 new infections (78 per cent) identified in the 24 hours to the afternoon of Wednesday Apr 1 were asymptomatic”. They say that the 36 symptomatic cases “involved arrivals from overseas”, quoting China’s National Health Commission.

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The new BMJ data is hugely important as the majority of new information and findings released daily worldwide is from the potentially small proportion of people who have shown symptoms, sought hospital help, undertook a test and tested positive.

This is different to previous epidemics such as SARS, where most infections were symptomatic and could be traced.

Ultimately, widespread antibody testing, which is still not imminent, will be able to tell us how many people have already had COVID-19. This will give a better approximation of the total number of infections. This will be important in making decisions on lifting social distancing measures.

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FILE PHOTO: Scientist Linqi Zhang in his laboratory at Tsinghua University's Research Center f
Scientist Linqi Zhang demonstrates work in his laboratory where he researches novel coronavirus disease (COVID-19) antibodies for possible use in a drug at Tsinghua University's Research Center for Public Health in Beijing, China on Mar 30, 2020. (Photo: REUTERS/Thomas Peter)

For example, if antibody testing suggests that a large proportion of the population has had COVID-19 already, there is a smaller chance of asymptomatic and undiagnosed cases spreading the infection once restrictions are lifted.

But if only a very small proportion of the population has had the infection, then lifting of social distancing measures may have to be delayed until vaccination strategies are ready to be implemented.

TWEAKING THE MODELS

Mathematical modelling allows us to develop a framework in which to mimic reality using formulaic expressions and parameters based on what we know about the virus spread.

Models can be refined to replicate known aspects – for example the number of reported infections and deaths due to COVID-19. Such models can then be used to make a prediction about the future.

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Ideally, a mathematical model for infectious disease spread should be based on parameters including the population of susceptible people, those exposed to the virus, those infected by the virus and those recovered from the virus.

The group infected by the virus can further be split into asymptomatic and symptomatic population groups that can be modelled separately.

REMAINING UNCERTAINTIES

But currently, there are large uncertainties around these numbers.

The new information will be crucial in addressing some of these uncertainties, and developing more robust and reliable modelling frameworks. Although modelling has strong predictive power, it is only as good as the data it uses.

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Bondi Beach drive-through testing centre for the coronavirus disease (COVID-19) in Sydney
Medical personnel administer tests for the coronavirus disease (COVID-19) at the Bondi Beach drive-through testing centre in Sydney, Australia, April 7, 2020. REUTERS/Loren Elliott

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The data currently being used is from people who have tested positive to COVID-19 infections. And if asymptomatic infections are a large proportion of COVID-19 infections, as the recent estimates seem to suggest, then a number of model parameters potentially need to be refined and reconsidered.

We don’t know how many people current models assume to be asymptomatic, but it could be different to the newly suggested 78 per cent.

Increasing this number would considerably reduce the case fatality rate – the proportion of deaths per number of infections. While the number of deaths related to COVID-19 are clearly countable, this new evidence suggests that there are a lot more infections than we thought, with a large proportion asymptomatic.

There is also very little information available to estimate the model parameter describing the time it takes for an infection to progress from asymptomatic to symptomatic.

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One study from Singapore suggested that progression occurs within one to three days. Confirming this will notably change the model predictions.

So while the new study suggests a large proportion of people may have already had COVID-19, we can’t say this for sure. Ultimately, we need a large blanket antibody testing strategy to confirm it.

Only then can we discuss whether the UK has reached “herd immunity” – whereby enough people have been infected to become immune to the virus – for this pandemic, and think about relaxing social distancing measures.

Hopefully such a test will be available very soon.

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Jasmina Panovska-Griffiths is Senior Research Fellow and Lecturer in Mathematical Modelling at University College London. This commentary first appeared on The Conversation.

Source: CNA/el

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