PARIS: One in three people who recover from COVID-19 suffer from a neurological or psychiatric diagnosis six months on, according to the largest study so far published on the mental toll that long-COVID-19 takes on survivors.
Authors said the research, printed on Wednesday (Apr 7) in The Lancet Psychiatry journal, proved that COVID-19 patients were significantly more likely to develop brain conditions than those suffering from other respiratory tract infections.
Studying the health records of more than 230,000 patients who had recovered from COVID-19, they found that 34 per cent were diagnosed with a neurological or psychiatric condition within six months.
The most common conditions were anxiety (17 per cent of patients) and mood disorders (14 per cent).
For 13 per cent of patients, the disorders were their first diagnosis of a mental health issue.
Incidence of neurological disorders such as brain haemorrhage (0.6 per cent), stroke (2.1 per cent) and dementia (0.7 per cent) was lower overall than for psychiatric disorders, but the risk for brain disorders was generally higher in patients who had severe COVID-19.
The authors also examined data from more than 100,000 patients diagnosed with influenza and more than 236,000 diagnosed with any respiratory tract infection.
They found there was overall a 44 per cent greater risk of neurological and mental health diagnoses after COVID-19 than after a flu, and a 16 per cent higher risk than with respiratory tract infections.
Paul Harrison, lead author from the University of Oxford, said that while the individual risk of neurological and psychiatric orders from COVID-19 was small, the overall effect across the global population could prove to be "substantial".
"Many of these conditions are chronic," he said.
"As a result, health care systems need to be resourced to deal with the anticipated need, both within primary and secondary care services."
Patients hospitalised with severe COVID-19 were at great risk of developing long-term conditions, according to the analysis.
For example, 46 per cent of patients who needed intensive care were diagnosed with neurological or psychiatric conditions within six months of recovery.
The data showed 2.7 per cent of people needing intensive care suffered a subsequent brain haemorrhage, compared to 0.3 per cent of people who were not hospitalised.
And nearly 7 per cent of those needing intensive care suffered a stroke, compared with 1.3 per cent of patients who did not
Writing in a linked comment article, Jonathan Rogers from University College London, said further research was needed on the long-term neurological and psychiatric outcomes among COVID-19 patients.
"Sadly, many of the disorders identified in this study tend to be chronic or recurrent, so we can anticipate that the impact of COVID-19 could be with us for many years," said Rogers, who was not involved in the study.
"It is clear from this study that the impact COVID-19 is having on individuals mental health can be severe," said Lea Milligan, CEO of the MQ Mental Health research group.
"This is contributing to the already rising levels of mental illness and requires further, urgent research."