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Commentary: A blood test that screens for multiple cancers at once promises to boost early detection

Multicancer early detection tests are likely to transform cancer screening in the near future, particularly if they receive strong government support, says a researcher.

SEATTLE: Detecting cancer early before it spreads throughout the body can be lifesaving. This is why doctors recommend regular screening for several common cancer types, using a variety of methods. Colonoscopies, for example, screen for colon cancer, while mammograms screen for breast cancer.

While important, getting all these tests done can be logistically challenging, expensive and sometimes uncomfortable for patients. But what if a single blood test could screen for most common cancer types all at once?

This is the promise of multicancer early detection tests, or MCEDs. This year, US President Joe Biden identified developing MCED tests as a priority for the Cancer Moonshot, a US$1.8 billion federal effort to reduce the cancer death rate and improve the quality of life of cancer survivors and those living with cancer.

As a laboratory medicine physician and researcher who develops molecular tests for cancer, I believe MCED tests are likely to transform cancer screening in the near future, particularly if they receive strong federal support to enable rapid innovation.


MCED tests are different from existing liquid biopsies because they are trying to detect early-stage cancer, when there aren’t that many tumour cells yet. Detecting these cancer cells can be challenging early on because noncancer cells also shed DNA into the bloodstream.

Since most of the circulating DNA in the bloodstream comes from noncancer cells, detecting the presence of a few molecules of cancer DNA is like finding a needle in a haystack.

Making things even more difficult, blood cells shed abnormal DNA naturally with ageing, and these strands can be confused for circulating cancer DNA. This phenomenon, known as clonal hematopoiesis, confounded early attempts at developing MCED tests, with too many false positive results.

Fortunately, newer tests are able to avoid blood cell interference by focusing on a type of “molecular barcode” embedded in the cancer DNA that identifies the tissue it came from. These barcodes are a result of DNA methylation, naturally existing modifications to the surface of DNA that vary for each type of tissue in the body.

For example, lung tissue has a different DNA methylation pattern than breast tissue. Furthermore, cancer cells have abnormal DNA methylation patterns that correlate with cancer type. By cataloging different DNA methylation patterns, MCED tests can focus on the sections of DNA that distinguish between cancerous and normal tissue and pinpoint the cancer’s origin site.


There are currently several MCED tests in development and in clinical trials. No MCED test is currently approved by the US Food and Drug Administration (FDA) or recommended by medical societies.

In 2021, the biotech company GRAIL launched the first commercially available MCED test in the US. Its Galleri test claims to detect more than 50 different types of cancers.

At least two other US-based companies, Exact Sciences and Freenome, and one Chinese company, Singlera Genomics, have tests in development. Some of these tests use different cancer detection methods in addition to circulating tumour DNA, such as looking for cancer-associated proteins in blood.

MCED tests are not yet typically covered by insurance. GRAIL’s Galleri test is currently priced at US$949, and the company offers a payment plan for people who have to pay out of pocket.

US legislators have introduced a Bill in Congress to provide Medicare coverage for MCED tests that obtain FDA approval. It is unusual for Congress to consider legislation devoted to a single lab test, and this highlights both the scale of the medical market for MCED and concerns about disparities in access without coverage for these expensive tests.


Figuring out how MCED tests should be implemented in the clinic will take many years. Researchers and clinicians are just beginning to address questions on who should be tested, at what age, and how past medical and family history should be taken into account. Setting guidelines for how doctors will further evaluate positive MCED results is just as important.

There is also concern that MCED tests may result in overdiagnoses of low-risk, asymptomatic cancers better left undetected. This happened with prostate cancer screening. Previously, guidelines recommended that all men ages 55 to 69 regularly get blood tests to determine their levels of PSA, a protein produced by cancerous and noncancerous prostate tissue.

But now the recommendation is more nuanced, with screening suggested on an individual basis that takes into account personal preferences.

Another concern is that further testing to confirm positive MCED results will be costly and a burden to the medical system, particularly if a full-body scan is required. The out-of-pocket cost for an MRI, for example, can run up to thousands of dollars.

And patients who get a positive MCED result but are unable to confirm the presence of cancer after extensive imaging and other follow-up tests may develop lifelong anxiety about a potentially missed diagnosis and continue to take expensive tests in fruitless search for a tumour.

Despite these concerns, early clinical studies show promise. A 2020 study of more than 10,000 previously undiagnosed women found 26 of 134 women with a positive MCED test were confirmed to have cancer.

A 2021 study sponsored by GRAIL found that half of the more than 2,800 patients with a known cancer diagnosis had a positive MCED test and only 0.5 per cent of people confirmed to not have cancer had a false positive test. The test performed best for patients with more advanced cancers but did detect about 17 per cent of the patients who had very-early-stage disease.

MCED tests may soon revolutionise the way clinicians approach cancer screening. The question is whether the health care system is ready for them.

Colin Pritchard is Professor of Laboratory Medicine and Pathology at the School of Medicine, University of Washington. This commentary first appeared on The Conversation.

Source: Others/el


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